Tissue Transglutaminase

The tissue transglutaminase (tTG) test is a blood test used to diagnose celiac disease, an autoimmune disorder that affects the small intestine. Celiac disease is caused by a reaction to gluten, a protein found in wheat, barley, and rye. The tTG test measures the level of antibodies against tissue transglutaminase in the blood. Tissue transglutaminase is an enzyme that plays a role in the immune response to gluten. In individuals with celiac disease, the immune system produces antibodies against tissue transglutaminase in response to gluten, which can cause damage to the lining of the small intestine. The tTG test is typically ordered if an individual is experiencing symptoms of celiac disease, such as diarrhea, abdominal pain, bloating, or weight loss. It may also be ordered if an individual has a family history of celiac disease or if they have other autoimmune disorders. Before the tTG test, an individual may need to follow a gluten-free diet for a period of time to ensure that the results are accurate. If the test results are positive, a biopsy of the small intestine may be performed to confirm the diagnosis of celiac disease. The tTG test is a reliable and non-invasive method for diagnosing celiac disease. It is important to diagnose celiac disease early and begin a gluten-free diet to prevent long-term complications, such as malnutrition, osteoporosis, and an increased risk of certain cancers. It is important to note that the tTG test is not a screening test for celiac disease and should only be ordered if an individual is showing symptoms or has a family history of the disease. It is also important to work with a healthcare professional to determine the best course of action if celiac disease is diagnosed.

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